Expression and function of interferon lambda receptor 1 variants

FEBS Lett. 2024 Oct 22. doi: 10.1002/1873-3468.15041. Online ahead of print.

Abstract

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell-type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces. This review will examine the evidence suggesting a role for IFNLR1 transcriptional variants in mediating cell responsiveness to IFNL ligand exposure and regulation of pathway activity.

Keywords: IFNLR1; innate immunity; interferon lambda; receptor isoforms.

Publication types

  • Review