Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

Pathol Res Pract. 2024 Nov:263:155657. doi: 10.1016/j.prp.2024.155657. Epub 2024 Oct 16.

Abstract

Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.

Keywords: Cancer; Cell death; Disulfidptosis; Long non-coding RNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death
  • Endoplasmic Reticulum Stress / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms* / genetics
  • Neoplasms* / therapy
  • Oxidative Stress
  • RNA, Long Noncoding* / genetics
  • Signal Transduction / genetics

Substances

  • RNA, Long Noncoding