New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct(14;14) and inv(14)

A Aurias; M F Croquette; J P Nuyts; C Griscelli; B Dutrillaux

doi:10.1007/BF00278811

New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct(14;14) and inv(14)

Hum Genet. 1986 Jan;72(1):22-4. doi: 10.1007/BF00278811.

Authors

A Aurias, M F Croquette, J P Nuyts, C Griscelli, B Dutrillaux

PMID: 3943860
DOI: 10.1007/BF00278811

Abstract

From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes. Smaller clones with the same inv(14) were observed in two other cases. Similar breakpoints may exist, both for t(14;14) and inv(14): q11.1/q11.2 and q32, and it is postulated that the rearrangements are related to a recombination of the alpha-chain of the T-cell receptor and IgH clusters of genes.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Ataxia Telangiectasia / genetics*
Child
Chromosome Banding
Chromosome Inversion*
Chromosome Mapping
Chromosomes, Human, 13-15*
Clone Cells
Female
Humans
Karyotyping
Male
Translocation, Genetic*