Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects

Ann A Zalucky; Michael A Matthay; Lorraine B Ware

doi:10.1016/j.ccm.2024.08.003

Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects

Clin Chest Med. 2024 Dec;45(4):809-820. doi: 10.1016/j.ccm.2024.08.003. Epub 2024 Sep 20.

Authors

Ann A Zalucky¹, Michael A Matthay², Lorraine B Ware³

Affiliations

¹ Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, M-917, Box 0624, San Francisco, CA 94143-0624, USA; Department of Critical Care Medicine, Alberta Health Services and University of Calgary, Calgary, Canada. Electronic address: [email protected].
² Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, M-917, Box 0624, San Francisco, CA 94143-0624, USA.
³ Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 777 Preston Research Building 2220, Pierce Avenue, Nashville, TN 37232-6307, USA.

PMID: 39442999
DOI: 10.1016/j.ccm.2024.08.003

Abstract

Biomarkers are an important tool aiding researchers in the study of acute respiratory distress syndrome (ARDS). Mechanisms involving injury to the alveolar-capillary membrane, endothelium and epithelium resulting in lung inflammation and alterations in coagulation pathways have been validated in human trials and have been used to discover promising phenotypes that share similar characteristics and differential treatment responses. The emergence of powerful point-of-care technologies will enable the prospective study of biomarkers for future enrichment trials with the goal of transforming biomarkers into the clinical realm to inform delivery of personalized medicine at the bedside.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Biomarker; Pathobiology; Proteins.

Publication types

Review

MeSH terms

Biomarkers* / blood
Humans
Respiratory Distress Syndrome* / blood
Respiratory Distress Syndrome* / diagnosis
Respiratory Distress Syndrome* / physiopathology
Respiratory Distress Syndrome* / therapy

Substances

Biomarkers