Mortality Rates after Tuberculosis Treatment, Georgia, USA, 2008-2019

Emerg Infect Dis. 2024 Nov;30(11):2261-2270. doi: 10.3201/eid3011.240329.

Abstract

Limited data exist on mortality rates after tuberculosis (TB) treatment in the United States. We analyzed mortality rates for all adults in Georgia, USA, who had a TB diagnosis and finished treatment during January 1, 2008-December 31, 2019. We obtained posttreatment mortality rate data from the National Death Index and calculated standardized mortality ratios (SMRs) for TB treatment survivors and the general Georgia population. Among 3,182 TB treatment survivors, 233 (7.3%) had died as of December 31, 2019. The overall TB cohort age- and sex-adjusted SMR was 0.89 (95% CI 0.73-1.05). The SMR among US-born TB treatment survivors was 1.56 (95% CI 1.36-1.77). In the TB cohort, US-born status, HIV co-infection, excess alcohol use, diabetes mellitus, and end-stage renal disease were associated with increased risk for death after TB treatment. TB treatment survivors could benefit from improved linkage to primary and HIV comprehensive care to prevent posttreatment death.

Keywords: Georgia; HIV; HIV/AIDS and other retroviruses; United States; bacteria; mortality; respiratory infections; tuberculosis; tuberculosis and other mycobacteria.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antitubercular Agents / therapeutic use
  • Female
  • Georgia / epidemiology
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology
  • HIV Infections / mortality
  • History, 21st Century
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Tuberculosis* / drug therapy
  • Tuberculosis* / epidemiology
  • Tuberculosis* / mortality
  • Young Adult

Substances

  • Antitubercular Agents