Critical-sized bone defects present a major challenge in healthcare, necessitating innovative solutions like bone tissue engineering (BTE) to address these issues. Surface engineering of bone scaffolds plays a crucial role in BTE by integrating natural polymers with advanced techniques to closely replicate the bone microenvironment, enhancing cellular responses such as adhesion, proliferation, and osteogenic differentiation. Natural polymers like collagen, chitosan, gelatin, hyaluronic acid, and alginate are used in various surface modification methods, including physical adsorption, covalent immobilization, electrospinning, and layer-by-layer assembly. This review provides a thorough analysis of these surface modification strategies across metallic, ceramic, and polymeric scaffolds, along with characterization methodologies, preclinical studies, and future prospects. By analysing recent research, the review offers valuable insights for advancing natural polymer-based surface engineering and developing next-generation scaffolds with improved bone regenerative capabilities.
Keywords: BTE; Chitosan; Collagen; Natural polymers; Surface modification.
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