Next-Generation Sequencing Reveals the Novel HLA-DQA1*06:01:04 Allele in a Bone Marrow Donor

HLA. 2024 Oct;104(4):e15729. doi: 10.1111/tan.15729.

Authors

Ahmed Gaballa^{1

2

3}, Anna Söderström¹, Nina Lundin¹, Torsten Eich¹

Affiliations

¹ Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
² Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
³ Department of Clinical Biochemistry, National Liver Institute, Menoufia University, Egypt.

PMID: 39462172
DOI: 10.1111/tan.15729

Abstract

A single nucleotide mismatch within exon 2 of HLA-DQA1 differentiates the novel DQA1*06:01:04 allele from DQA1*06:01:01:01.

Keywords: HLA; NGS; allele; typing.

© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MeSH terms

Alleles*
Base Sequence
Bone Marrow
Bone Marrow Transplantation
Exons*
HLA-DQ alpha-Chains* / genetics
High-Throughput Nucleotide Sequencing*
Histocompatibility Testing* / methods
Humans
Polymorphism, Single Nucleotide
Sequence Alignment
Sequence Analysis, DNA / methods
Tissue Donors*

Substances

HLA-DQ alpha-Chains
HLA-DQA1 antigen