Dynamics of the human bile acid metabolome during weight loss

Andreas Schmid; Gerhard Liebisch; Ralph Burkhardt; Hannah Belikan; Sebastian Köhler; Daniel Steger; Leonie Schweitzer; Jörn Pons-Kühnemann; Thomas Karrasch; Andreas Schäffler

doi:10.1038/s41598-024-75831-1

Dynamics of the human bile acid metabolome during weight loss

Sci Rep. 2024 Oct 28;14(1):25743. doi: 10.1038/s41598-024-75831-1.

Affiliations

¹ Basic Research Laboratory of Molecular Endocrinology, Adipocyte Biology and Biochemistry, University of Giessen, Giessen, Germany.
² Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany.
³ Department of Internal Medicine - Endocrinology, Diabetology, Metabolism, University of Giessen, Giessen, Germany.
⁴ Medical Statistics, Institute of Medical Informatics, University of Giessen, Giessen, Germany.
⁵ Department of Internal Medicine - Endocrinology, Diabetology, Metabolism, University of Giessen, Giessen, Germany. [email protected].
⁶ Department of Internal Medicine, Giessen University Hospital, Klinikstrasse 33, 35392, Giessen, Germany. [email protected].

Abstract

Bile acids (BA) are supposed to cause metabolic alterations after bariatric surgery (BS). Here we report the longitudinal dynamics of the human BA metabolome by LC-MS/MS after BS versus low calory diet (LCD) in two obesity cohorts over 12 months. Rapid and persistent oscillations of 23 BA subspecies could be identified with highly specific patterns in BS vs. LCD. TCDCA, GLCA, and TLCA represent most promising candidates for drug development.

Keywords: Bariatric surgery; Bile acids; Low calory diet; Metabolome; Obesity; Roux-en-Y gastric bypass; Weight loss.

MeSH terms

Adult
Bariatric Surgery
Bile Acids and Salts* / metabolism
Chromatography, Liquid
Female
Humans
Male
Metabolome*
Middle Aged
Obesity* / metabolism
Tandem Mass Spectrometry
Weight Loss*

Substances

Bile Acids and Salts