Successful Repeated Use of a Pathogen Adsorbing Biomimetic Device for the Adjunct Treatment of a SARS-CoV-2 Reinfection and Subsequent Infections with Different Multiresistant Bacteria

Reuben Okioma; Khalida Soki; Alexander Hay; Jan T Kielstein

doi:10.1159/000541422

Successful Repeated Use of a Pathogen Adsorbing Biomimetic Device for the Adjunct Treatment of a SARS-CoV-2 Reinfection and Subsequent Infections with Different Multiresistant Bacteria

Case Rep Nephrol Dial. 2024 Oct 17;14(1):171-177. doi: 10.1159/000541422. eCollection 2024 Jan-Dec.

Authors

Reuben Okioma¹, Khalida Soki², Alexander Hay³, Jan T Kielstein⁴

Affiliations

¹ Department of Critical Care, The Nairobi Hospital, Nairobi, Kenya.
² Department of Nephrology, The Nairobi Hospital, Nairobi, Kenya.
³ Breen Medical, Dublin, Ireland.
⁴ Medical Clinic V Nephrology, Rheumatology, Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany.

Abstract

Introduction: The Seraph^® 100 Microbind^® Affinity Filter is a biomimetic adsorbent device that can remove pathogens from the blood.

Case presentation: Here, we report the successful use of the Seraph^® 100 to treat both a SARS-CoV-2 reinfection leading to severe COVID-19 pneumonia as well as subsequent secondary lung infections including Acinetobacter baumannii, Serratia marcescens, and Pseudomonas aeruginosa multidrug-resistant bacteria. To our knowledge, this 46-year-old black male is the first patient in which four treatments with this pathogen adsorber, one for a viral and three for different bacterial infections, have been successfully used.

Conclusion: The Seraph^® 100 can be easily and successfully used in conjunction with standard (anti-infective) treatment.

Keywords: Blood purification; Multidrug-resistant bacteria; Sepsis.

Publication types

Case Reports

Grants and funding

No funding was received for this study.