Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

Slavica Dimitrieva; Jon M Harrison; Jonathan Chang; Michelle Piquet; Mari Mino-Kenudson; Millicent Gabriel; Vivek Sagar; Heiko Horn; Kasper Lage; Julie Kim; Gang Li; Shaobu Weng; Cynthia Harris; Anupriya S Kulkarni; David T Ting; Motaz Qadan; Peter J Fagenholz; Cristina R Ferrone; Angelo L Grauel; Tyler Laszewski; Alina Raza; Markus Riester; Tim Somerville; Joel P Wagner; Glenn Dranoff; Jeffrey A Engelman; Audrey Kauffmann; Rebecca Leary; Andrew L Warshaw; Keith D Lillemoe; Carlos Fernández-Del Castillo; David A Ruddy; Andrew S Liss; Viviana Cremasco

doi:10.1158/2767-9764.CRC-23-0489

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

Cancer Res Commun. 2024 Dec 1;4(12):3049-3066. doi: 10.1158/2767-9764.CRC-23-0489.

Authors

Slavica Dimitrieva^#¹, Jon M Harrison^#², Jonathan Chang^#³, Michelle Piquet⁴, Mari Mino-Kenudson⁵, Millicent Gabriel⁴, Vivek Sagar⁶, Heiko Horn², Kasper Lage², Julie Kim⁴, Gang Li¹, Shaobu Weng³, Cynthia Harris⁵, Anupriya S Kulkarni⁷, David T Ting⁷, Motaz Qadan², Peter J Fagenholz², Cristina R Ferrone², Angelo L Grauel⁶, Tyler Laszewski³, Alina Raza³, Markus Riester⁶, Tim Somerville⁴, Joel P Wagner⁶, Glenn Dranoff⁸, Jeffrey A Engelman⁸, Audrey Kauffmann¹, Rebecca Leary³, Andrew L Warshaw², Keith D Lillemoe², Carlos Fernández-Del Castillo², David A Ruddy⁴, Andrew S Liss², Viviana Cremasco³

Affiliations

¹ Oncology Data Science, Novartis Biomedical Research, Basel, Switzerland.
² Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
³ Oncology Translational Research, Novartis Biomedical Research, Cambridge, Massachusetts.
⁴ Oncology Innovative Targets and Technologies, Novartis Biomedical Research, Cambridge, Massachusetts.
⁵ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
⁶ Oncology Data Science, Novartis Biomedical Research, Cambridge, Massachusetts.
⁷ Mass General Cancer Center, Boston, Massachusetts.
⁸ Oncology, Novartis Biomedical Research, Cambridge, Massachusetts.

^# Contributed equally.

Abstract

Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.

MeSH terms

Fibroblasts / metabolism
Fibroblasts / pathology
Humans
Pancreatic Neoplasms* / genetics
Pancreatic Neoplasms* / pathology
Sequence Analysis, RNA / methods
Single-Cell Analysis* / methods
Tumor Microenvironment / genetics

Abstract

MeSH terms

Grants and funding