Natural history of salivary gland secretory carcinoma: A REFCOR study

Marie Magana; Sebastien Vergez; Benjamin Verillaud; Renaud Garrel; Diane Evrard; François Mouawad; Ludovic de Gabory; Nicolas Fakhry; Franck Jegoux; Olivier Malard; Christine Bach; Pierre Philouze; Karine Aubry; Olivier Mauvais; Antoine Moya Plana; Jean Paul Marie; Bertrand Baujat; Sarah Atallah

doi:10.1016/j.suronc.2024.102159

Natural history of salivary gland secretory carcinoma: A REFCOR study

Surg Oncol. 2024 Dec:57:102159. doi: 10.1016/j.suronc.2024.102159. Epub 2024 Oct 28.

Authors

Marie Magana¹, Sebastien Vergez², Benjamin Verillaud³, Renaud Garrel⁴, Diane Evrard⁵, François Mouawad⁶, Ludovic de Gabory⁷, Nicolas Fakhry⁸, Franck Jegoux⁹, Olivier Malard¹⁰, Christine Bach¹¹, Pierre Philouze¹², Karine Aubry¹³, Olivier Mauvais¹⁴, Antoine Moya Plana¹⁵, Jean Paul Marie¹⁶, Bertrand Baujat¹⁷, Sarah Atallah¹⁸

Affiliations

¹ Sorbonne University, Tenon Hospital, APHP, ENT and Head and Neck Surgery Department, 4 Rue de la Chine, 75020, Paris, France. Electronic address: [email protected].
² Toulouse University, IUCT, ENT and Head and Neck Department, 1 Avenue Irene Joliot-Curie, 31100, Toulouse, France. Electronic address: [email protected].
³ Paris-Cite University, Lariboisiere Hospital, APHP, ENT Department, 2 Rue Ambroise Pare, 75010, Paris, France. Electronic address: [email protected].
⁴ Montpellier-Nimes University, Gui de Chaulliac Hospital, CHU Montpellier, ENT and Head and Neck Surgery Department, 80 Avenue Augustin Fliche, 34295, Montpellier, France. Electronic address: [email protected].
⁵ Paris-Cite University, Bichat Hospital, 46 Rue Henri Huchard, APHP, ENT and Head and Neck Surgery Department, 75018, Paris, France. Electronic address: [email protected].
⁶ Lille University, Claude Huriez Hospital, CHU Lille, Head and Neck Surgery Department, UMR9020 CNRS - U1277 Inserm, 59037, 1 Place de Verdun, Lille, France. Electronic address: [email protected].
⁷ Bordeaux University, Pellegrin Hospital, CHU Bordeaux, Head and Neck Surgery Department, Place Amélie Raba-Léon, 33076, Bordeaux, France. Electronic address: [email protected].
⁸ Aix-Marseille University, Conception Hospital, APHM, ENT and Head and Neck Surgery Department, 147 Boulevard Baille, 13005, Marseille, France. Electronic address: [email protected].
⁹ Rennes University, Pontchaillou Hospital, CHU Rennes, ENT Department, 2 Rue Henri Le Guilloux, 35000, Rennes, France. Electronic address: [email protected].
¹⁰ Nantes University, Hotel-Dieu Hospital, CHU Nantes, ENT and Head and Neck Surgery Department, 1 Place Alexis-Ricordeau, 44000, Nantes, France. Electronic address: [email protected].
¹¹ Ambroise Pare-Hartmann Private Hospital, 48 ter boulevard Victor Hugo, 92200, Neuilly-sur-Seine, France. Electronic address: [email protected].
¹² Claude Bernard Lyon 1 University, Croix Rousse Hospital, HCL, Head and Neck Surgery Department, 103 Grand Rue de la Croix-Rousse, 69004, Lyon, France. Electronic address: [email protected].
¹³ Limoges University, Dupuytren Hospital, CHU Limoges, ENT and Head and Neck Surgery Department, 2 Avenue Martin Luther King, 87000, Limoges, France. Electronic address: [email protected].
¹⁴ Besancon University, Jean Minjoz Hospital, ENT and Head and Neck Surgery Department, 3 boulevard Alexandre Fleming, 25000, Besançon, France. Electronic address: [email protected].
¹⁵ Paris Saclay University, Gustave Roussy Institute, Head and Neck Surgery Department, INSERM U981, 114 Rue Edouard Vaillant, 94805, Villejuif, France. Electronic address: [email protected].
¹⁶ Rouen University, Charles-Nicolle Hospital, CHU Rouen, ENT and Head and Neck Surgery Department, 37 boulevard Gambetta, 76000, Rouen, France. Electronic address: [email protected].
¹⁷ Sorbonne University, Tenon Hospital, APHP, ENT and Head and Neck Surgery Department, 4 Rue de la Chine, 75020, Paris, France. Electronic address: [email protected].
¹⁸ Sorbonne University, Tenon Hospital, APHP, ENT and Head and Neck Surgery Department, 4 Rue de la Chine, 75020, Paris, France. Electronic address: [email protected].

PMID: 39486243
DOI: 10.1016/j.suronc.2024.102159

Abstract

Background and objectives: Salivary gland Secretory Carcinoma (SC), characterized by Skalova in 2010 is a rare tumor studied within the REFCOR (French Network of experts on Rare Head and Neck Cancers). We conducted a prospective multicentric cohort study of 108 SC cases in the REFCOR database up to July 2021, analyzing diagnostic, therapeutic, and survival data.

Methods: Data was collected prospectively from diagnosis to the last update. Each patient had two histological readings including one by a REFCORpath pathologist, and all cases underwent molecular testing to confirm diagnosis. Statistical analyses were performed using R software.

Results: MRI was not contributive to malignancy diagnosis. After 2 histological readings, 79 % of patients were diagnosed, with 21 % requiring molecular testing to confirm diagnosis. Surgical treatment typically involved tumor excision and lymph node dissection. The tumor exhibited low lymph node involvement, with 95 % of patients being cN0, and no nodal metastases post-dissection. Five-year overall survival and recurrence-free survival were 91.4 % {95 % CI (0.84-1)} and 89 % {95 % CI (0.81; 0.98)} respectively, indicating a favorable prognosis.

Conclusions: SC is a rare and newly recognized tumor, with generally favorable outcomes. Our cohort, among the largest to date, provides valuable insights. Future research should refine treatment guidelines.

Keywords: Histopathology; REFCOR; Salivary gland cancers; Salivary secretory carcinoma; Survival analysis.

Publication types

Multicenter Study

MeSH terms

Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Salivary Gland Neoplasms* / mortality
Salivary Gland Neoplasms* / pathology
Salivary Gland Neoplasms* / surgery
Survival Rate
Young Adult