Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential

Sam C Ogden; Marc T Nishimura; Dmitry Lapin

doi:10.1016/j.pbi.2023.102481

Functional diversity of Toll/interleukin-1 receptor domains in flowering plants and its translational potential

Curr Opin Plant Biol. 2023 Oct 27:76:102481. doi: 10.1016/j.pbi.2023.102481. Online ahead of print.

Authors

Sam C Ogden¹, Marc T Nishimura², Dmitry Lapin³

Affiliations

¹ Department of Biology, Colorado State University, Fort Collins, CO 80523, USA; Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA.
² Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: [email protected].
³ Department of Biology, Translational Plant Biology, Utrecht University, 3584CH, Utrecht, the Netherlands. Electronic address: [email protected].

PMID: 39492368
DOI: 10.1016/j.pbi.2023.102481

Abstract

Across the Tree of Life, innate immunity and cell death mechanisms protect hosts from potential pathogens. In prokaryotes, animals, and flowering plants, these functions are often mediated by Toll/interleukin-1 receptor (TIR) domain proteins. Here, we discuss recent analyses of TIR biology in flowering plants, revealing (i) TIR functions beyond pathogen recognition, e.g. in the spatial control of immunity, and (ii) the existence of at least two pathways for TIR signaling in plants. Also, we discuss TIR-based strategies for crop improvement and argue for a need to better understand TIR functions outside of commonly studied dicot pathways for future translational work. Opinions of experts on emerging topics in basic and translational plant TIR research are presented in supplementary video interviews.

Keywords: Cell non-autonomous immunity; Crop improvement; Innate immunity; Plant immune system; Toll/interleukin-1 receptor (TIR).

Publication types

Review