Primary squamous cell carcinoma of the liver (PSCCL) is a rare intrahepatic primary tumor. Due to a lack of distinctive clinical presentations and radiological features, early diagnosis is challenging. The present study, describes a patient who initially presented with symptoms indicative of cholecystitis but was misdiagnosed with cholangiocarcinoma. It is hypothesized that fluctuations in carcinoembryonic antigen levels during laboratory tests can significantly aid the diagnosis, treatment and prognosis of tumors. Furthermore, imaging studies are essential for the early diagnosis of PSCCL and the exclusion of metastatic squamous cell carcinoma.
Keywords: hepatic malignancy; primary squamous cell carcinoma of the liver; squamous cell carcinoma.
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