[Au]/[Ag]-catalysed synthesis of non-hydrolysable C-glycosides

Org Biomol Chem. 2024 Nov 4. doi: 10.1039/d4ob01339e. Online ahead of print.

Abstract

Many C-glycosides are found in natural products, drugs and small molecular probes. Herein, we report the synthesis of C-glycosides by the [Au]/[Ag]-catalysed activation of ethynylcyclohexyl glycosyl carbonate donors. This mild, catalytic, fast and high yielding protocol enables the synthesis of a diverse array of C-glycosides that were otherwise challenging to synthesize.