Harnessing plant biosynthesis for the development of next-generation therapeutics

PLoS Biol. 2024 Nov 5;22(11):e3002886. doi: 10.1371/journal.pbio.3002886. eCollection 2024 Nov.

Abstract

Genomics-based predictions indicate that plants harbor the ability to make a vast array of as yet undiscovered chemistry. Recent advances open up the potential to harness this capability at unprecedented scale for the discovery and development of new therapeutics.

MeSH terms

  • Drug Discovery / methods
  • Genomics / methods
  • Humans
  • Plants* / genetics
  • Plants* / metabolism

Grants and funding

This work was supported by the Novozymes Prize 2023 (Novo Nordisk Foundation to A.O.), Wellcome Discovery Award #227375/Z/23/Z to A.O., NIH award 1RO1AT010593- 01 to A.O., the BBRSC Institute Strategic Programme Grant ‘Harnessing biosynthesis for sustainable food and health’ (BB/X01097X/1 to A.O.) and the John Innes Foundation (to A.O.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.