Pituitary hyperplasia secondary to primary hypothyroidism in adolescents: A medical case report and literature review

Xiangfeng Yuan; Jiangyu Zhu; Xiaoyu Su; Huiling Tan; Siqi Wang; Xueying Zheng; Yu Ding; Sumei Li

doi:10.1002/ccr3.9541

Pituitary hyperplasia secondary to primary hypothyroidism in adolescents: A medical case report and literature review

Clin Case Rep. 2024 Nov 5;12(11):e9541. doi: 10.1002/ccr3.9541. eCollection 2024 Nov.

Authors

Xiangfeng Yuan^{1

2}, Jiangyu Zhu³, Xiaoyu Su³, Huiling Tan¹, Siqi Wang¹, Xueying Zheng¹, Yu Ding¹, Sumei Li¹

Affiliations

¹ Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China.
² Department of Endocrinology, Funan Hospital of Traditional Chinese Medicine Fuyang Anhui China.
³ Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical College Bengbu Medical College Bengbu Anhui China.

Abstract

Prompt and precise diagnosis of pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is crucial to avoid unwarranted pituitary surgery and potential permanent impairment. Although PHPH may present similarly to pituitary adenoma, it is responsive to thyroxine therapy, underscoring the critical role of differential diagnosis in the treatment of adolescent patients.

Keywords: adolescent; case report; pituitary hyperplasia; primary hypothyroidism; review.