Factors affected the ovarian reserve after laparoscopic cystectomy for ovarian endometriomas

Objective: To identify related factors that affect the ovarian reserve after laparoscopic ovarian cystectomy in patients with endometriomas.

Study design: It was a retrospective cohort study performed in a tertiary-care university hospital. A total of 409 patients with endometriomas underwent laparoscopic ovarian cystectomy between June 2014 and November 2021.

Results: The demographic and operative data, including age, parity, body mass index, tumor size, operating time, and estimated blood loss were recorded. Serum anti-Mullerian hormone (AMH) levels were recorded preoperatively, as well as 10 days (immediately) and 6 months after the procedure respectively. The decrease of serum AMH level at 6 months after the surgery were 0.7 ± 1.6 ng/mL (22.5 ± 57.1 %) in the unilateral group and 1.5 ± 2.1 ng/mL (48.3 ± 65.6 %) in the bilateral group. The reduction in the serum AMH level at 10 days and 6 months after the operation were significant compared to the baseline level. The bilateral group has a significantly lower serum AMH level than that of the unilateral group in terms of 10 days and 6 months after operation (p < 0.001). Baseline serum AMH level < 2 ng/mL have shown less reduction in both 10 days group and 6 months group with odds ratio (OR) 0.36 (p = 0.01) and OR 0.264 (p < 0.001) respectively. Neither patient's age nor tumor size contributed to the decline of ovarian reserve.

Conclusions: Bilaterality and pre-operative serum AMH level are the two key factors that affect ovarian reserve after laparoscopic cystectomy.