Retinoblastoma, one of the most common intraocular malignancies in infants and young children, seriously affects the vision and life. The in-depth study of the origin and pathogenesis of retinoblastoma, which remain controversial, is crucial. This article summarizes the research progress on the cell origin of retinoblastoma and the second hit theory, aiming to provide a theoretical basis for the diagnosis, treatment, and prevention of retinoblastoma.
视网膜母细胞瘤（RB）是婴幼儿最常见的眼内恶性肿瘤，严重影响患儿的视力和生命。深入探讨RB的起源和发病机制，对于疾病的诊断、治疗和预防具有重要意义。RB的起源和发病机制眼科界一直存在争议。本文结合国内外最新相关研究结果，针对RB的起源细胞及二次突变学说等焦点问题进行分析和论述，旨在为RB的诊断、治疗和遗传咨询提供理论依据和参考。.