Paired electrocatalysis enabled oxidative coupling of styrenes with alkyl radicals

Org Biomol Chem. 2024 Dec 18;23(1):78-82. doi: 10.1039/d4ob01605j.

Abstract

A paired electrocatalysis strategy for intermolecular oxidative cross-dehydrocoupling between styrenes and ethers or p-methylphenol derivatives using ketone as a mild oxidant is described. This approach enables the generation of Csp3 carbon-centered radicals through anodic oxidation, followed by reductive coupling of ketones at the cathode, ultimately yielding valuable oxidative alkylation products.