Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review

Cancer Rep (Hoboken). 2024 Nov;7(11):e70021. doi: 10.1002/cnr2.70021.

Abstract

Background: Previous studies mainly concentrate on neoadjuvant chemotherapy (NACT) for delivery delay in FIGO Stage IB1-IIIB cervical cancer during pregnancy to prevent early preterm delivery while not affecting maternal outcome.

Case: Here, we described two pregnant patients with FIGO Stage IIIC cervical cancer about their diagnosis, treatment, and outcome. Both patients underwent cesarean delivery, left enlarged lymph node dissection, and longitudinal monitoring by circulating tumor DNA. Our study suggested that pregnant patient was completely response to NACT, which was confirmed by ctDNA monitoring, followed by left pelvic enlarged lymph node dissection during cesarean section and adjuvant chemoradiotherapy postpartum. The infant grew normally, without any evidence of chemotherapy-related side effects after delivery.

Conclusion: In pregnant women with advanced cervical cancer, longitudinal ctDNA monitoring might be able to evaluate maternal response to NACT and confirm if delivery delay to optimize fetal outcome would compacting the maternal outcomes or not. Cervical cancer may not transmit across the placental barrier and so it is safe for delayed delivery until fetal maturity in utero during pregnancy.

Keywords: advanced cervical cancer; chemoradiotherapy; circulating tumor DNA; neoadjuvant chemotherapy; pregnancy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cesarean Section
  • Circulating Tumor DNA* / blood
  • Circulating Tumor DNA* / genetics
  • Female
  • Humans
  • Lymph Node Excision
  • Neoadjuvant Therapy* / methods
  • Neoplasm Staging
  • Pregnancy
  • Pregnancy Complications, Neoplastic* / blood
  • Pregnancy Complications, Neoplastic* / diagnosis
  • Pregnancy Complications, Neoplastic* / drug therapy
  • Pregnancy Complications, Neoplastic* / pathology
  • Pregnancy Complications, Neoplastic* / therapy
  • Time-to-Treatment
  • Treatment Delay
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / drug therapy
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / therapy

Substances

  • Circulating Tumor DNA