Inclusiveness of the All of Us Research Program improves polygenic risk scores and fosters genomic medicine for all

Benson R Kidenya; Gerald Mboowa

doi:10.1038/s43856-024-00647-z

Inclusiveness of the All of Us Research Program improves polygenic risk scores and fosters genomic medicine for all

Commun Med (Lond). 2024 Nov 8;4(1):227. doi: 10.1038/s43856-024-00647-z.

Authors

Benson R Kidenya^{1

2}, Gerald Mboowa^{3

4

5}

Affiliations

¹ Department of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania. [email protected].
² Train-The-Trainers for Bioinformatics Community, Human Heredity and Health for Africa Bioinformatics Network (H3ABioNet), Cape Town, South Africa. [email protected].
³ Department of Immunology and Molecular Biology, College of Health Sciences, School of Biomedical Sciences, Makerere University, Kampala, Uganda.
⁴ The African Center of Excellence in Bioinformatics and Data-Intensive Sciences, the Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
⁵ Africa Centres for Disease Control and Prevention, African Union Commission, Addis Ababa, Ethiopia.

Abstract

Polygenic risk scores (PRS) show promise but have accuracy disparities across ancestries due to underrepresentation in the existing genomic databases. Here, we outline the initiative of All of Us Research Program in refining PRS and advancing genomic medicine for all.