Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms

Eur J Immunol. 2025 Jan;55(1):e202451387. doi: 10.1002/eji.202451387. Epub 2024 Nov 8.

Abstract

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14+ cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.

Keywords: aging; chronic inflammation; inflammaging; monocytes; myelodysplastic neoplasm (MDS).

Publication types

  • Letter

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging* / genetics
  • Aging* / immunology
  • Female
  • Humans
  • Inflammation / immunology
  • Lipopolysaccharide Receptors / genetics
  • Lipopolysaccharide Receptors / metabolism
  • Male
  • Middle Aged
  • Monocytes* / immunology
  • Myelodysplastic Syndromes* / genetics
  • Myelodysplastic Syndromes* / immunology
  • Transcriptome

Substances

  • Lipopolysaccharide Receptors