Transition to Enteral Triazole Antifungal Therapy for Pediatric Invasive Candidiasis: Secondary Analysis of a Multicenter Cohort Study Conducted by the Pediatric Fungal Network

J Pediatric Infect Dis Soc. 2024 Dec 30;13(12):633-638. doi: 10.1093/jpids/piae116.

Abstract

Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was successful in 66 participants who transitioned to enteral therapy.

Keywords: antifungal agent; candidemia; fluconazole; invasive candidiasis; oral drug administration.

Publication types

  • Multicenter Study

MeSH terms

  • Administration, Intravenous
  • Adolescent
  • Antifungal Agents* / administration & dosage
  • Antifungal Agents* / therapeutic use
  • Candidiasis, Invasive* / drug therapy
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Humans
  • Infant
  • Male
  • Treatment Outcome
  • Triazoles / administration & dosage
  • Triazoles / therapeutic use

Substances

  • Antifungal Agents
  • Triazoles