A small molecule that reshapes the chromatin dynamics of FOXA1

Khadija Shahed Khan; Billy Wai-Lung Ng

doi:10.1016/j.molcel.2024.10.019

A small molecule that reshapes the chromatin dynamics of FOXA1

Mol Cell. 2024 Nov 7;84(21):4049-4051. doi: 10.1016/j.molcel.2024.10.019.

Authors

Khadija Shahed Khan¹, Billy Wai-Lung Ng²

Affiliations

¹ School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
² School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: [email protected].

PMID: 39515290
DOI: 10.1016/j.molcel.2024.10.019

Abstract

In this issue, Won et al.¹ report a covalent ligand binding the pioneer transcription factor FOXA1, altering its function and remodeling chromatin. This important finding highlights the potential of small molecules to modulate transcription factor activity and demonstrates the promise of chemical proteomics in discovering first-in-class ligands.

MeSH terms

Animals
Chromatin Assembly and Disassembly / drug effects
Chromatin* / genetics
Chromatin* / metabolism
Hepatocyte Nuclear Factor 3-alpha* / genetics
Hepatocyte Nuclear Factor 3-alpha* / metabolism
Humans
Ligands

Substances

Hepatocyte Nuclear Factor 3-alpha
Chromatin
FOXA1 protein, human
Ligands