Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy

Shinichiro Akichika; Tsutomu Suzuki

doi:10.1016/j.molcel.2024.10.014

Cap-specific m⁶Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy

Mol Cell. 2024 Nov 7;84(21):4051-4052. doi: 10.1016/j.molcel.2024.10.014.

Authors

Shinichiro Akichika¹, Tsutomu Suzuki²

Affiliations

¹ Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
² Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. Electronic address: [email protected].

PMID: 39515291
DOI: 10.1016/j.molcel.2024.10.014

Abstract

In this issue of Molecular Cell, An et al.¹ reports a novel function of cap-specific m⁶Am modification acting as an anti-terminator for premature RNA polymerase II transcription by sequestering a transcriptional terminator PCF11. This study provides new insights into RNA modifications in transcriptional control and cancer treatment.

MeSH terms

Humans
Neuroblastoma* / genetics
Neuroblastoma* / metabolism
Neuroblastoma* / pathology
RNA Caps / genetics
RNA Caps / metabolism
RNA Polymerase II* / genetics
RNA Polymerase II* / metabolism
Transcription, Genetic

Substances

RNA Polymerase II
RNA Caps