Evidence for an HPV one-dose schedule

Margaret Stanley; Anne Schuind; Kirthini K Muralidharan; Dominique Guillaume; Victoria Willens; Hannah Borda; Marley Jurgensmeyer; Rupali Limaye

doi:10.1016/j.vaccine.2024.01.046

Evidence for an HPV one-dose schedule

Vaccine. 2024 Jul 11:42 Suppl 2:S16-S21. doi: 10.1016/j.vaccine.2024.01.046. Epub 2024 Nov 7.

Authors

Margaret Stanley¹, Anne Schuind², Kirthini K Muralidharan³, Dominique Guillaume⁴, Victoria Willens⁵, Hannah Borda⁵, Marley Jurgensmeyer⁵, Rupali Limaye⁶

Affiliations

¹ Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, CB2 1QP, United Kingdom.
² PATH, USA.
³ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA. Electronic address: [email protected].
⁴ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; School of Nursing, Johns Hopkins University, 525 N Wolfe St, Baltimore, MD, 21205, USA.
⁵ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA.
⁶ International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of International Health, Division of Global Disease Epidemiology and Control, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Coalition to Strengthen the HPV Immunization Community (CHIC), USA; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA; Department of Epidemiology, Division of Infectious Disease Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA.

PMID: 39521566
DOI: 10.1016/j.vaccine.2024.01.046

Abstract

The World Health Organization has recently updated their dosing schedule recommendations for the human papillomavirus (HPV) vaccine to include a single-dose schedule. We review the biologic plausibility of a single dose, the evidence from clinical trials, post-licensure observational studies, and mathematical modeling for a single-dose schedule. We also discuss the implications of countries switching to a single-dose program from a two or three-dose schedule. Finally, we review the countries that have currently switched to or introduced the vaccine with a single-dose schedule.

Keywords: Dosing Schedule; HPV Vaccine; Immunisation Programmes.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Female
Humans
Immunization Schedule*
Models, Theoretical
Papillomavirus Infections* / prevention & control
Papillomavirus Vaccines* / administration & dosage
Papillomavirus Vaccines* / immunology
Vaccination / methods
World Health Organization

Substances

Papillomavirus Vaccines