Clinical outcomes following acute sore throat assessment at community pharmacy versus general practice: a retrospective, longitudinal, data linkage study

J Antimicrob Chemother. 2025 Jan 3;80(1):227-237. doi: 10.1093/jac/dkae400.

Abstract

Background: To date, no research has compared longer-term outcomes (antibiotic provision; re-consultations; hospital admissions for quinsy; cost-effectiveness) following presentation with acute sore throat at general practice (GP) versus newer, pharmacy-led services.

Methods: A retrospective, longitudinal cohort study of sore throat consultations between 1 November 2018 and 28 February 2020 either with the Wales pharmacy-led sore throat test and treat (STTT) service or with a healthcare professional at GP. Individual-level pharmacy consultation data from the national Choose Pharmacy IT application were securely uploaded to the Secure Anonymised Information Linkage Databank and linked to routinely collected, anonymized, population-scale, individual-level, anonymized health and administrative data.

Results: Of 72 736 index consultations, 6495 (8.9%) were with STTT and 66 241 (91.1%) with GP. Antibiotic provision at the index consultation was 1382 (21%) with STTT and 25 506 (39%) with GP [adjusted odds ratio (AOR), 0.30; 95% CI, 0.27 to 0.32]. Antibiotic provision within 28 days of index occurred in 1820 (28%) STTT and 26 369 (40%) GP consultations (AOR, 0.44; 95% CI, 0.41 to 0.47). GP re-consultation rate within 28 days of index date was 21% (n = 1389) with STTT compared with 7.4% (n = 4916) with GP (AOR, 3.8; 95% CI, 3.5 to 4.1). Coding limitations may lead to overestimates of GP re-consultations rates in the STTT group. Hospital admissions for quinsy were rare in both STTT (n = 20, 0.31%) and GP (n = 274, 0.41%) (AOR, 0.68; 95% CI, 0.43 to 1.1). STTT was less costly than consultation with GP.

Conclusions: The pharmacy-led STTT service is safe, cost-effective, and contributes to antimicrobial stewardship.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents* / therapeutic use
  • Cost-Benefit Analysis
  • Female
  • General Practice*
  • Hospitalization / statistics & numerical data
  • Humans
  • Information Storage and Retrieval
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pharmacies
  • Pharyngitis* / drug therapy
  • Pharyngitis* / microbiology
  • Referral and Consultation / statistics & numerical data
  • Retrospective Studies
  • Treatment Outcome
  • Wales
  • Young Adult

Substances

  • Anti-Bacterial Agents

Grants and funding