Carbon-nitride-based (CN-based) materials have shown great potential in combination therapy in recent years. Due to their outstanding biocompatibility, ease of modification, and adjustable band-gap position, CN-based materials can be applied as photosensitizers in photodynamic therapy (PDT) and light-driven water-splitting catalysts in gas therapy. After doping with other elements, the photocatalytic performance of CN-based materials will be enhanced, and more interesting functions will be obtained. In addition, the large specific surface area also promotes CN-based materials as drug carriers combined with other therapeutic modalities to achieve combination therapy. This Review analyzes and summarizes the latest research on CN-based materials in combined therapies, such as PDT with photothermal therapy (PTT), PDT with sonodynamic therapy (SDT), PDT with drug therapy, PDT with gene therapy, gas therapy with PDT, and bioimaging-guided combined therapy. In particular, the applications of CN-based materials in gas and gene combination therapy are summarized for the first time. Finally, the current challenges faced by CN-based materials in combination therapy are further discussed.
Keywords: carbon nitride; combination treatment; gas therapy; gene therapy; photodynamic therapy.