Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

Lynn M Knowles; Carolin Wolter; Stefan Linsler; Simon Müller; Steffi Urbschat; Ralf Ketter; Andreas Müller; Xiangda Zhou; Bin Qu; Sebastian Senger; Jürgen Geisel; Tim Schmidt; Hermann Eichler; Jan Pilch

doi:10.1158/2767-9764.CRC-24-0164

Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

Cancer Res Commun. 2024 Dec 1;4(12):3124-3136. doi: 10.1158/2767-9764.CRC-24-0164.

Authors

Affiliations

¹ Institute of Clinical Hemostaseology and Transfusion Medicine, Saarland University and University Medical Center, Homburg, Germany.
² Department of Neurosurgery, Saarland University and University Medical Center, Homburg, Germany.
³ Clinic for Diagnostic and Interventional Radiology, Saarland University and University Medical Center, Homburg, Germany.
⁴ Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University and University Medical Center, Homburg, Germany.
⁵ Clinical Chemistry and Laboratory Medicine, Saarland University and University Medical Center, Homburg, Germany.

^# Contributed equally.

Abstract

High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.

MeSH terms

Animals
Blood Coagulation
Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Cell Line, Tumor
Cell Proliferation
Focal Adhesion Kinase 1 / genetics
Focal Adhesion Kinase 1 / metabolism
Focal Adhesion Protein-Tyrosine Kinases / genetics
Focal Adhesion Protein-Tyrosine Kinases / metabolism
Glioma* / genetics
Glioma* / pathology
Humans
Mice

Substances

Focal Adhesion Protein-Tyrosine Kinases
Focal Adhesion Kinase 1