Non-coding RNAs (ncRNAs) as therapeutic targets and biomarkers in oligodendroglioma

Mohd Imran; Abdulmalik Saleh Alfawaz Altamimi; M Arockia Babu; Kavita Goyal; Irwanjot Kaur; Sachin Kumar; Naveen Sharma; M Ravi Kumar; Fadiyah Jadid Alanazi; Abeer Nuwayfi Alruwaili; Nouf Afit Aldhafeeri; Haider Ali

doi:10.1016/j.prp.2024.155708

Non-coding RNAs (ncRNAs) as therapeutic targets and biomarkers in oligodendroglioma

Pathol Res Pract. 2024 Nov 6:264:155708. doi: 10.1016/j.prp.2024.155708. Online ahead of print.

Authors

Affiliations

¹ Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia; Center for Health Research, Northern Border University, Arar, Saudi Arabia.
² Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
³ Institute of Pharmaceutical Research, GLA UNIVERSITY, Mathura, UP 281406, India.
⁴ Department of Biotechnology, Graphic Era (Deemed to be University), Clement Town, Dehradun 248002, India.
⁵ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan 303012, India.
⁶ NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India. Electronic address: [email protected].
⁷ Chandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri, Mohali, Punjab 140307, India.
⁸ Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh 531162, India.
⁹ Center for Health Research, Northern Border University, Arar, Saudi Arabia; Public Health Nursing Department, College of Nursing, Northern Border University, Arar, Saudi Arabia.
¹⁰ Department of Nursing Administration and Education, College of Nursing, Jouf University, Al Jouf City 72388, Saudi Arabia.
¹¹ College of Nursing, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
¹² Division of Translational Health Research, Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan.

PMID: 39531874
DOI: 10.1016/j.prp.2024.155708

Abstract

Oligodendrogliomas (ODGs) are neuroepithelial tumors that need personalized treatment plans because of their unique molecular and histological features. Non-coding RNAs form an epigenetic class of molecules that act as the first steps in gene regulation. They consist of microRNAs, long non-coding RNAs, and circular RNAs. These molecules significantly participate in ODG pathogenesis by regulating ODG initiation, progression, and treatment response. This review is designated to analyze the literature and describe the genomic profile of ODGs, the complex actions of ncRNAs in ODGs pathogenesis and treatment, and their roles as appropriate biomarkers and as one of the precision mechanisms action targets, such as antisense oligonucleotides, small interfering RNAs, gene therapy vectors, peptide nucleic acids, and small molecule inhibitors. Overall, ncRNAs considerably alter the pathological spectrum of ODGs by influencing fundamental processes in tumor biology. Applying ncRNAs in a clinical context exhibits promise for enhanced diagnosis and individualized therapeutic interventions. Nevertheless, the delivery efficacy and potential adverse "off-target" sequels retain the main obstacles undermining clinical potential. Continuous research and technological advancements in ncRNAs offer new insights and promising prospects for revolutionizing oligodendroglioma care, leading to better, personalized treatment outcomes.

Keywords: NcRNAs; Oligodendrogliomas; Precision medicine; Therapeutic strategies; Treatment response.

Publication types

Review