Background: Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection for which the standard of care is co-trimoxazole. However, safety concerns and intolerance may compromise its utility.
Objectives: To evaluate the safety and efficacy of the combination of echinocandins and clindamycin to treat PcP.
Patients and methods: We investigated 14 patients treated with a co-trimoxazole-free combined regimen that included echinocandins and clindamycin.
Results: Clinical cure was achieved in 8 out of 14 patients, while 5 had a fatal outcome due to their primary disease; however, only one patient died due to PcP.
Conclusions: Echinocandin and clindamycin may be a safe and effective alternative treatment for patients who cannot be given co-trimoxazole for PcP.
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