Risk of uveitis among E-Cigarette Users: a multi-institutional TriNetX study

Alan Y Hsu; Yu-Hsun Wang; Ning-Yi Hsia; Chun-Ting Lai; Hou-Ting Kuo; Bing-Qi Wu; Chun-Ju Lin; Chun-Chi Chiang; Yi-Ching Shao; Huan-Sheng Chen; Yi-Yu Tsai; James Cheng-Chung Wei

doi:10.1016/j.ophtha.2024.11.008

Risk of uveitis among E-Cigarette Users: a multi-institutional TriNetX study

Ophthalmology. 2024 Nov 11:S0161-6420(24)00703-6. doi: 10.1016/j.ophtha.2024.11.008. Online ahead of print.

Authors

Affiliations

¹ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.
² Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
³ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Optometry, Asia University, Taichung, Taiwan.
⁴ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of General Medicine, China Medical University Hospital, Taichung, Taiwan.
⁵ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Optometry, Asia University, Taichung, Taiwan. Electronic address: [email protected].
⁶ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Optometry, Asia University, Taichung, Taiwan. Electronic address: [email protected].
⁷ Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
⁸ An-Shin Dialysis Center, Excelsior Renal Service Co., Ltd., Taiwan Branch, Taichung, Taiwan.
⁹ Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan; Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.

PMID: 39536980
DOI: 10.1016/j.ophtha.2024.11.008

Abstract

Purpose: To determine the risk of uveitis among e-cigarette users METHODS: The TriNetX database was used to recruit adult patients with and without a history of e-cigarette usage. The primary outcome was the incidence of new-onset uveitis.

Results: E-cigarette users were associated with an increased risk for uveitis compared to non-users (HR: 2.53, CI: 2.33-2.76). Subgroup analysis revealed an increased risk of uveitis among e-cigarette users aged 18-39 years (HR: 2.59, CI: 2.11-3.17), 40-64 years (HR: 2.20, CI: 1.95-2.48) and ≥65 years (HR: 3.15, CI: 2.72-3.64).

Conclusions: An increased risk for uveitis was seen among e-cigarette users compared to non-users.

Keywords: TriNetX; cohort; e-cigarette; smoking; uveitis; vaping.