Gut microbiota plays an important role in maintaining the normal function of intestinal tract, regulating the body's immunity, metabolism and other physiological processes. In recent years, the theory that gut microbiota dysbiosis affects the disease occurrence of various organ systems through the gut-organ axis has been gradually confirmed. Placental diseases of pregnancy includes early onset preeclampsia, fetal growth restriction, etc., the pathogenesis of which is unclear, but can cause adverse pregnancy outcomes. Researches show that gut microbiota dysbiosis has a certain correlation with the occurrence of placental diseases, and its mechanism may affect the occurrence of placental diseases by regulating systemic and local placental metabolism, inflammatory response and immune response. This article reviews the research progress on the effects of maternal gut microbiota dysbiosis on the occurrence of placenta-derived diseases, and provides clues for exploring the application of gut microecology to the prevention and treatment of placenta-derived diseases.
肠道菌群在维持肠道正常功能、调节机体免疫、代谢等多种生理过程中均发挥重要作用。近年来，肠道菌群失调通过肠-器官轴影响各器官系统疾病发生的理论逐渐得到证实。妊娠胎盘源性疾病包括早发型子痫前期、胎儿生长受限等，其发病机制不清，可导致母儿不良妊娠结局。研究显示，肠道菌群失调与胎盘源性疾病的发生有一定的相关性，其机制可能通过调控全身系统性与胎盘局部的代谢、炎症反应与免疫反应进而影响胎盘源性疾病的发生。本文对母体肠道菌群失调影响胎盘源性疾病发生的相关研究进展进行阐述，为探索肠道微生态应用于胎盘源性疾病的防治提供思路。.