The Effectiveness of Web-Based Dyadic Interventions on Depression, Psychological Distress, Stress, and Quality of Life Among Persons With Cancer and Informal Caregivers: A Meta-Analysis

Objective: To assess the impact of web-based dyadic interventions on depression, distress, stress, and quality of life among persons with cancer and their informal caregivers.

Methods: A systematic literature search was conducted in PubMed, EMBASE, MEDLINE, PsycINFO, the Cochrane Library, CNKI, and Wanfang Data for articles in English or Chinese through August 2023. The methodological quality of the studies was assessed using the Cochrane Risk of Bias tool and the Methodological Index for Nonrandomized Studies. Data were analyzed using RevMan 5.4.

Results: The meta-analysis included 9 articles with 1,030 participants, consisting of 5 randomized controlled trials and 4 quasi-experimental trials. Significant improvements were observed in the quality of life for persons with cancer, particularly in physical (SMD = 0.32, 95% CI [0.10, 0.54], P = .004) and functional (SMD = 0.28, 95% CI [0.06, 0.50], P = .01) well-being. For informal caregivers, interventions significantly reduced depression (SMD = -0.58, 95% CI [-1.06, -0.10], P = .02), distress (SMD = -0.39, 95% CI [-0.76, -0.03], P = .03), and stress (SMD = -0.62, 95% CI [-1.04, -0.21], P = .003).

Conclusion: Web-based dyadic interventions significantly enhance the physical and functional well-being of persons with cancer and reduce depression, distress, and stress among their informal caregivers.

Implications for nursing practice: The study underscores the importance of dyadic interventions in offering comprehensive support. Personalized, web-based dyadic interventions show promise for tailored, holistic care in the future.