The pyroptosis and fibrotic diseases: a bibliometric analysis from 2010 to 2024

Long Zhu; Lijia Ou; Binjie Liu; Yang Yang; Chang Su; Ousheng Liu; Hui Feng

doi:10.1186/s13643-024-02703-0

The pyroptosis and fibrotic diseases: a bibliometric analysis from 2010 to 2024

Syst Rev. 2024 Nov 13;13(1):279. doi: 10.1186/s13643-024-02703-0.

Authors

Long Zhu^#¹, Lijia Ou^#², Binjie Liu¹, Yang Yang¹, Chang Su³, Ousheng Liu¹, Hui Feng⁴

Affiliations

¹ Academician Workstation for Oral-Maxillofacial and Regenerative Medicine, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan, 410008, China.
² State Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, ChineseAcademy of Medical Sciences, Sichuan University, Chengdu, Sichuan, 610041, China.
³ Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
⁴ Academician Workstation for Oral-Maxillofacial and Regenerative Medicine, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan, 410008, China. [email protected].

^# Contributed equally.

Abstract

Background: Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field.

Methods: We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method.

Results: A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years.

Conclusion: We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.

MeSH terms

Bibliometrics*
Fibrosis*
Humans
Pyroptosis*