Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules

Toya Tabei; Kyoko Nakagawa-Goto; Yohei Saito

doi:10.1039/d4cc05370b

Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules

Chem Commun (Camb). 2024 Nov 14. doi: 10.1039/d4cc05370b. Online ahead of print.

Authors

Toya Tabei¹, Kyoko Nakagawa-Goto^{1

2}, Yohei Saito^{1

3}

Affiliations

¹ School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. [email protected].
² Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA.
³ Advanced Preventive Medical Sciences Research Center, Kanazawa University, Takara-machi, Kanazawa, Ishikawa 920-8640, Japan.

PMID: 39539242
DOI: 10.1039/d4cc05370b

Abstract

We successfully found that boroxazolidone can dissociate under aqueous conditions, which were applicable to a solution containing proteins. The immobilization of a newly synthesized diarylborinic acid on beads enabled the capture and release of target proteins of bioactive compounds through boroxazolidone formation and dissociation.