Duration of diabetes, glycemic control, and low heart rate variability: The Atherosclerosis Risk in Communities (ARIC) study

Mary R Rooney; Faye L Norby; Elsayed Z Soliman; Lin Yee Chen; Elizabeth Selvin; Justin B Echouffo-Tcheugui

doi:10.1016/j.jdiacomp.2024.108903

Duration of diabetes, glycemic control, and low heart rate variability: The Atherosclerosis Risk in Communities (ARIC) study

J Diabetes Complications. 2024 Dec;38(12):108903. doi: 10.1016/j.jdiacomp.2024.108903. Epub 2024 Nov 6.

Authors

Mary R Rooney¹, Faye L Norby², Elsayed Z Soliman³, Lin Yee Chen⁴, Elizabeth Selvin⁵, Justin B Echouffo-Tcheugui⁶

Affiliations

¹ Department of Epidemiology and Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: [email protected].
² Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
³ Epidemiological Cardiology Research Center, School of Medicine, Wake Forest Univ, Winston-Salem, NC, United States.
⁴ Lillehei Heart Institute and Department of Medicine (Cardiovascular Division), Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, United States.
⁵ Department of Epidemiology and Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
⁶ Department of Epidemiology and Welch Center for Prevention, Epidemiology, & Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University, Baltimore, MD, United States.

PMID: 39541734
PMCID: PMC11588038 (available on 2025-12-01)
DOI: 10.1016/j.jdiacomp.2024.108903

Abstract

Persons with long-standing, poorly controlled diabetes or recent hyperglycemia had the highest burden of cardiac autonomic neuropathy. Cardiac autonomic neuropathy contributed to elevated long-term incidence of cardiovascular disease and mortality even in persons with well-controlled diabetes.

Keywords: Biomarkers; Cardiac autonomic neuropathy; Diabetes; Heart rate variability; Prospective cohort.

MeSH terms

Atherosclerosis / epidemiology
Blood Glucose / analysis
Blood Glucose / metabolism
Cardiovascular Diseases / epidemiology
Cardiovascular Diseases / etiology
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / physiopathology
Diabetic Angiopathies / epidemiology
Diabetic Cardiomyopathies / epidemiology
Diabetic Neuropathies* / epidemiology
Diabetic Neuropathies* / physiopathology
Female
Glycemic Control*
Heart Rate* / physiology
Humans
Hyperglycemia / epidemiology
Incidence
Male
Middle Aged
Risk Factors
Time Factors

Substances

Blood Glucose

Abstract

MeSH terms

Substances

Grants and funding