PRIMALung (EORTC-1901): PRophylactic cerebral irradiation (PCI) or active brain MAgnetic resonance imaging (MRI) surveillance in small-cell lung cancer (SCLC) patients

Antonin Levy; Thierry Berghmans; Michael Koller; Beatrice Fournier; Murielle Mauer; Nicolaus Andratschke; Corinne Faivre-Finn

doi:10.1016/j.lungcan.2024.107993

PRIMALung (EORTC-1901): PRophylactic cerebral irradiation (PCI) or active brain MAgnetic resonance imaging (MRI) surveillance in small-cell lung cancer (SCLC) patients

Lung Cancer. 2024 Dec:198:107993. doi: 10.1016/j.lungcan.2024.107993. Epub 2024 Oct 24.

Authors

Antonin Levy¹, Thierry Berghmans², Michael Koller³, Beatrice Fournier⁴, Murielle Mauer⁴, Nicolaus Andratschke⁵, Corinne Faivre-Finn⁶

Affiliations

¹ Department of Radiation Oncology, Gustave Roussy, Villejuif, France; Gustave Roussy, Inserm U1030, Université Paris-Saclay, Villejuif, France; Faculté de Médecine, Université Paris Saclay, Le Kremlin-Bicêtre, France. Electronic address: [email protected].
² Thoracic Oncology, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium.
³ Centre for Clinical Studies, University Hospital Regensburg, Regensburg, Germany.
⁴ European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium.
⁵ Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
⁶ The Christie NHS Foundation Trust, University of Manchester, Manchester, UK. Electronic address: [email protected].

PMID: 39541773
DOI: 10.1016/j.lungcan.2024.107993

Abstract

The PRIMALung EORTC-1901 trial investigates brain MRI ± PCI in all-stages of SCLC, aiming for non-inferior survival, improve cognition in the era of immunotherapy. @finn_corinne.

Publication types

Randomized Controlled Trial
Review

MeSH terms

Brain / diagnostic imaging
Brain / pathology
Brain / radiation effects
Brain Neoplasms* / diagnostic imaging
Brain Neoplasms* / radiotherapy
Cranial Irradiation* / adverse effects
Female
Humans
Lung Neoplasms* / diagnostic imaging
Lung Neoplasms* / pathology
Lung Neoplasms* / radiotherapy
Magnetic Resonance Imaging* / methods
Male
Neoplasm Staging
Small Cell Lung Carcinoma* / diagnostic imaging
Small Cell Lung Carcinoma* / pathology
Small Cell Lung Carcinoma* / radiotherapy