Bacterial small RNA makes a big impact for gut colonization

Elena Monzel; Mahesh S Desai

doi:10.1016/j.chom.2024.10.010

Bacterial small RNA makes a big impact for gut colonization

Cell Host Microbe. 2024 Nov 13;32(11):1875-1877. doi: 10.1016/j.chom.2024.10.010.

Authors

Elena Monzel¹, Mahesh S Desai²

Affiliations

¹ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
² Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. Electronic address: [email protected].

PMID: 39541940
DOI: 10.1016/j.chom.2024.10.010

Abstract

The functions of non-coding small RNAs (sRNAs) within the human microbiome remain largely unexplored. In this Cell Host & Microbe issue, El Mouali et al. identify Segatella RNA colonization factor (SrcF), a sRNA from a prevalent gut bacterium Segatella copri. SrcF promotes colonization of S. copri by regulating bacterial degradation of complex dietary carbohydrates.

MeSH terms

Animals
Dietary Carbohydrates / metabolism
Gastrointestinal Microbiome* / genetics
Gastrointestinal Tract / microbiology
Gene Expression Regulation, Bacterial
Humans
RNA, Bacterial* / genetics
RNA, Bacterial* / metabolism
RNA, Small Untranslated / genetics
RNA, Small Untranslated / metabolism

Substances

RNA, Bacterial
RNA, Small Untranslated
Dietary Carbohydrates