Application of botulinum toxin A in tissue repair and regeneration

Toxicon. 2024 Nov 12:108172. doi: 10.1016/j.toxicon.2024.108172. Online ahead of print.

Abstract

Tissue repair and regeneration present significant clinical challenges. Despite the array of treatments currently available in this domain, the urgent demand for innovative therapies persists, with the goal of enhancing patient quality of life. Recently, the application of botulinum neurotoxin type A (BoNT/A) has expanded within the realm of tissue repair and regeneration. This review critically examines the utilization of BoNT/A, specifically focusing on its vascular effects, potential in nerve regeneration, and contributions to bone healing. This analysis not only offers fresh insights into the diverse mechanisms of action of BoNT/A but also explores additional therapeutic possibilities for patients.

Keywords: angiogenesis; botulinum neurotoxin type A; nerve regeneration; tissue regeneration.