Photooxidative C-C double bond cleavage of β-enaminocarbonyl compounds: toward selective N-formylation of amines

Org Biomol Chem. 2024 Nov 15. doi: 10.1039/d4ob01688b. Online ahead of print.

Abstract

A photooxidative C-C double bond cleavage of electron-deficient β-enaminocarbonyl compounds possessing a silyl group at the α-position to the nitrogen atom using methylene blue (MB) as the photosensitizer was explored. Photochemically generated 1O2 was added across the CC bond with the aid of a tethered silyl group to cleave it and form N-formylamines. This reaction protocol exhibited compatibility with numerous β-enaminocarbonyl substrates, including those with various N-alkyl, N-benzyl and N-aryl substituents.