SnapShot: Targeted protein degradation

Yu Ding; Boxun Lu

doi:10.1016/j.cell.2024.10.025

SnapShot: Targeted protein degradation

Cell. 2024 Nov 14;187(23):6784-6784.e1. doi: 10.1016/j.cell.2024.10.025.

Authors

Yu Ding¹, Boxun Lu²

Affiliations

¹ State Key Laboratory of Medical Neurobiology, Neurology Department at Huashan Hospital, School of Life Sciences, Fudan University, Shanghai 200433, China.
² State Key Laboratory of Medical Neurobiology, Neurology Department at Huashan Hospital, School of Life Sciences, Fudan University, Shanghai 200433, China. Electronic address: [email protected].

PMID: 39547212
DOI: 10.1016/j.cell.2024.10.025

Abstract

Targeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate a protein of interest. Emerging technologies are opening avenues in drug discovery and functional characterization of intracellular, membrane, and extracellular proteins. To view this SnapShot, open or download the PDF.

MeSH terms

Animals
Humans
Proteins* / chemistry
Proteins* / metabolism
Proteolysis*

Substances

Proteins