Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging

Gabriela Ueta Ortiz; Ellen Cristini de Freitas

doi:10.1016/j.arr.2024.102582

Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging

Ageing Res Rev. 2024 Dec:102:102582. doi: 10.1016/j.arr.2024.102582. Epub 2024 Nov 14.

Authors

Gabriela Ueta Ortiz¹, Ellen Cristini de Freitas²

Affiliations

¹ Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil.
² Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, USP, Ribeirão Preto, São Paulo, Brazil; School of Physical Education and Sport of Ribeirão Preto (EEFERP/USP), University of São Paulo, Ribeirão Preto, Brazil. Electronic address: [email protected].

PMID: 39547367
DOI: 10.1016/j.arr.2024.102582

Abstract

With an aging population, the investigation of therapies that promote healthy aging becomes increasingly urgent. Here we discuss how Semaglutide can be a potential therapy to contribute to this goal by targeting key hallmarks of aging, such as inflammation, oxidative stress and stem cell exhaustion.

Keywords: Healthy aging; Inflammation; Oxidative stress; Semaglutide; Stem cell exhaustion.

Publication types

Review

MeSH terms

Aging / drug effects
Aging / metabolism
Animals
Glucagon-Like Peptides* / pharmacology
Glucagon-Like Peptides* / therapeutic use
Healthy Aging / drug effects
Healthy Aging / physiology
Humans
Inflammation / drug therapy
Inflammation / metabolism
Oxidative Stress* / drug effects

Substances

semaglutide
Glucagon-Like Peptides