Antioxidative hydrogel based on hyaluronic acid/polyethylene glycol loaded with shikonin-coated flexible liposome and evaluation of its therapeutic effect on eczema

Eczema, a common skin condition, is gaining attention due to its increasing annual prevalence and severe influence on both bodily and mental health. Existing treatments for this disease often have significant side effects and safety concerns. Comfrey, a traditional Chinese herbal remedy, is commonly used to treat skin conditions. Shikonin, the primary active compound in comfrey, has demonstrated efficacy in treating eczema. Herein, a flexible liposome-containing SHI was dispersed in hydrogels based on hyaluronic acid (HA) and polyethylene glycol(PEG) for the treatment of eczema. The hydrogel performed well in delaying drug release. SHI-F-Gel demonstrated notable antioxidant properties, effectively eliminating over 80 % of free radicals. Compared to the SHI solution, SHI-F-Gel significantly increased drug skin retention by 312.9 %. In animal studies, SHI-F-Gel administration reduced epidermal thickness in the affected area by approximately 36.8 % and increased collagen deposition by 90.23 %. Additionally, SHI-F-Gel inhibited the expression of pro-inflammatory cytokines interleukin-4 (IL-4) and IL-17. This observed reduction in inflammation suggests that the treatment is effective. In conclusion, the flexible SHI-based liposome hydrogel demonstrates excellent adhesion and biocompatibility, making it a promising candidate for enhancing eczema treatment.