Romer-EPTI: Rotating-view motion-robust super-resolution EPTI for SNR-efficient distortion-free in-vivo mesoscale diffusion MRI and microstructure imaging

Purpose: To overcome the major challenges in diffusion MRI (dMRI) acquisition, including limited SNR, distortion/blurring, and susceptibility to motion artifacts.

Theory and methods: A novel Romer-EPTI technique is developed to achieve SNR-efficient acquisition while providing distortion-free imaging, minimal spatial blurring, high motion robustness, and simultaneous multi-TE imaging. It introduces a ROtating-view Motion-robust supEr-Resolution technique (Romer) combined with a distortion/blurring-free Echo Planar Time-resolved Imaging (EPTI) readout. Romer enhances SNR through simultaneous multi-thick-slice acquisition with rotating-view encoding, while providing high motion-robustness via a high-fidelity, motion-aware super-resolution reconstruction. Instead of EPI, the in-plane encoding is performed using EPTI readout to prevent geometric distortion, T₂/T₂*-blurring, and importantly, dynamic distortions that could introduce additional blurring/artifacts after super-resolution reconstruction due to combining volumes with inconsistent geometries. This further improves effective spatial resolution and motion robustness. Additional developments include strategies to address slab-boundary artifacts, achieve minimized TE and optimized readout for additional SNR gain, and increase robustness to strong phase variations at high b-values.

Results: Using Romer-EPTI, we demonstrated distortion-free whole-brain mesoscale in-vivo dMRI at both 3T (500-μm isotropic [iso] resolution) and 7T (485-μm iso resolution) for the first time. Motion experiments demonstrated the technique's motion robustness and its ability to obtain high-resolution diffusion images in the presence of subject motion. Romer-EPTI also demonstrated high SNR gain and robustness in high b-value (b = 5000 s/mm²) and time-dependent dMRI.

Conclusion: The high SNR efficiency, improved image quality, and motion robustness of Romer-EPTI make it a highly efficient acquisition for high-resolution dMRI and microstructure imaging.