Template and Solid-State-Assisted Assembly of an M9L6 Expanded Coordination Cage for Medium-Sized Molecule Encapsulation

Kenta Iizuka; Hiroki Takezawa; Makoto Fujita

doi:10.1021/jacs.4c14509

Template and Solid-State-Assisted Assembly of an M₉L₆ Expanded Coordination Cage for Medium-Sized Molecule Encapsulation

J Am Chem Soc. 2024 Nov 27;146(47):32311-32316. doi: 10.1021/jacs.4c14509. Epub 2024 Nov 18.

Authors

Kenta Iizuka¹, Hiroki Takezawa¹, Makoto Fujita^{1

2

3}

Affiliations

¹ Department of Applied Chemistry, School of Engineering, The University of Tokyo, Mitsui Link Lab Kashiwanoha 1, FS CREATION, 6-6-2 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan.
² Tokyo College, UT Institutes for Advanced Study, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.
³ Division of Advanced Molecular Science, Institute for Molecular Science (IMS), 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.

Abstract

The M₆L₄ cage, self-assembling from six Pd(II) or Pt(II) 90-degree blocks and four triazine-cored triangular ligands, has an effective hydrophobic cavity of about 450 Å³ capable of encapsulating one or more small molecules. Here, from the same components, we successfully constructed an M₉L₆ cage with an internal volume expanded to 1540 Å³ via the self-assembly of an M₈L₆ precursor using pillar[5]arene as a template. This cage retains the high molecular recognition ability of the M₆L₄ cage while recognizing medium-sized guest molecules with molecular weights of up to ∼1600.