Qualitative and Quantitative Luminescence Detection of 2,6-Dipicolinic Acid and Levofloxacin Based on a High-Nuclearity Eu(III) Nanomolecular Sensor

Shimin Yang; Jiazhao Lin; Shiqing Wang; Xiaojun Wu; Desmond Schipper; Xiaoping Yang

doi:10.1021/acs.analchem.4c04407

Qualitative and Quantitative Luminescence Detection of 2,6-Dipicolinic Acid and Levofloxacin Based on a High-Nuclearity Eu(III) Nanomolecular Sensor

Anal Chem. 2024 Nov 18. doi: 10.1021/acs.analchem.4c04407. Online ahead of print.

Authors

Shimin Yang¹, Jiazhao Lin¹, Shiqing Wang¹, Xiaojun Wu², Desmond Schipper³, Xiaoping Yang¹

Affiliations

¹ Zhejiang Key Laboratory of Carbon Materials, Key Lab of Biohealth Materials and Chemistry of Wenzhou, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
² Department of Neurosurgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
³ Department of Chemistry, The University of Texas at Austin, 105 E. 24th Street - A5300, Austin, Texas 78712-1224, United States.

PMID: 39556047
DOI: 10.1021/acs.analchem.4c04407

Abstract

Rapid and accurate testing of 2,6-dipicolinic acid (DPA) and levofloxacin (LFX) has been attracting much attention due to the fact that the former is an important biomarker of anthrax spores and the latter is a third-generation fluoroquinolone drug and has been recognized as an important environmental pollutant. Herein, we report the preparation of a 13-metal Eu(III) nanomolecular sensor (molecular sizes: 2.0 × 2.4 × 3.2 nm) bearing a new flexible Schiff base ligand for luminescence testing of DPA and LFX with high selectivity and sensitivity. The rapid enhancement of the Eu(III) luminescence of 1 caused by DPA and LFX is expressed by fitting equation I_615nm = k × [C] + a, which can be used to quantitatively detect DPA and LFX concentrations in CH₃CN, fetal calf serum (FCS), and a real drug. The response times of 1 to DPA and LFX are less than ten seconds, with detection limits as low as 3.78 × 10^-2 to 2.71 nM. The test strips containing 1, as well as 1@SA films, can be used to qualitatively detect DPA and LFX by the color changes under the irradiation of UV light.