A new stress test for ryanodine receptors

Ben Short

doi:10.1085/jgp.202413716

A new stress test for ryanodine receptors

J Gen Physiol. 2024 Dec 2;156(12):e202413716. doi: 10.1085/jgp.202413716. Epub 2024 Nov 19.

Author

Ben Short¹

Affiliation

¹ Science Writer, Rockefeller University Press, New York, NY, USA.

PMID: 39560719
PMCID: PMC11577274 (available on 2025-05-19)
DOI: 10.1085/jgp.202413716

Abstract

JGP study (Steinz et al. https://doi.org/10.1085/jgp.202313515) reveals that oxidative stress can induce stable posttranslational modifications of RyR1 that increase the channel's open probability and could therefore disrupt muscle contractility.

MeSH terms

Animals
Humans
Muscle Contraction / physiology
Oxidative Stress* / physiology
Protein Processing, Post-Translational
Ryanodine Receptor Calcium Release Channel* / metabolism

Substances

Ryanodine Receptor Calcium Release Channel