Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities

Sherif S Abdel Mageed; Hanan Elimam; Ahmed E Elesawy; Ahmed I Abulsoud; Ahmed Amr Raouf; Manar Mohammed El Tabaa; Osama A Mohammed; Mohamed Bakr Zaki; Mai A Abd-Elmawla; Walaa A El-Dakroury; Safwat Abdelhady Mangoura; Mahmoud A Elrebehy; Mohammed S Elballal; Aya A Mohamed; Alaa Ashraf; Mustafa Ahmed Abdel-Reheim; Ali M S Eleragi; Hussein Abdellatif; Ahmed S Doghish

doi:10.1007/s00210-024-03603-9

Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities

Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov 19. doi: 10.1007/s00210-024-03603-9. Online ahead of print.

Authors

Sherif S Abdel Mageed¹, Hanan Elimam², Ahmed E Elesawy³, Ahmed I Abulsoud^{4

5}, Ahmed Amr Raouf¹, Manar Mohammed El Tabaa⁶, Osama A Mohammed⁷, Mohamed Bakr Zaki², Mai A Abd-Elmawla⁸, Walaa A El-Dakroury⁹, Safwat Abdelhady Mangoura¹, Mahmoud A Elrebehy¹⁰, Mohammed S Elballal^{3

11}, Aya A Mohamed¹², Alaa Ashraf¹³, Mustafa Ahmed Abdel-Reheim¹⁴, Ali M S Eleragi¹⁵, Hussein Abdellatif^{16

17}, Ahmed S Doghish^{18

19}

Affiliations

¹ Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
² Biochemistry, Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Menoufia, Egypt.
³ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
⁴ Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
⁵ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt.
⁶ Pharmacology & Environmental Toxicology, Environmental Studies & Research Institute (ESRI), University of Sadat City, Sadat City, 32897, Menoufia, Egypt.
⁷ Department of Pharmacology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
⁸ Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
⁹ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
¹⁰ Department of Biochemistry, Faculty of Pharmacy, Galala University, New Galala City, 43713, Suez,, Egypt.
¹¹ BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University, Goyang, Republic of Korea.
¹² Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
¹³ Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
¹⁴ Department of Pharmacology, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia. [email protected].
¹⁵ Department of Microorganisms and Clinical Parasitology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
¹⁶ Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
¹⁷ Department of Anatomy and Embryology, Faculty of Medicine, University of Mansoura, Mansoura, 35516, Egypt.
¹⁸ Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt. [email protected].
¹⁹ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt. [email protected].

PMID: 39560752
DOI: 10.1007/s00210-024-03603-9

Abstract

Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body's uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3' untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.

Keywords: Biomarker; Diagnosis; Gouty arthritis; Therapy; miRNA.

Publication types

Review