The key locations of freshwater input driving Atlantic Meridional Overturning Circulation (AMOC) slowdown and their climate responses remain inconclusive. Using a state-of-the-art global climate model, we conduct freshwater hosing experiments to reexamine AMOC sensitivity and its climate impacts. The Irminger basin emerges as the most effective region for additional freshwater fluxes, causing the greatest AMOC weakening. While global temperature and precipitation responses are relatively homogeneous, subcontinental responses-especially in the northern mid-latitudes-are heterogeneous. At high latitudes, sea ice responses to freshwater fluxes and associated ice-albedo feedbacks determine temperature changes. In tropical and extratropical regions, temperature dynamics are shaped by atmospheric circulation and oceanic heat transport. Precipitation shows seasonal and regional variability due to altered surface turbulent heat flux and the southward movement of the Intertropical Convergence Zone (ITCZ). The widespread heterogeneity in climate extremes underscores the need to monitor freshwater release regions linked to AMOC slowdown. These findings hold vital implications for understanding paleoclimate and future AMOC impacts.